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Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma.

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作者单位: Bioinformatics and Systems Biology Graduate Program, University of California San Diego, San Diego, CA, USA. [1] Department of Medicine, University of California San Diego, San Diego, CA, USA. [2] Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA. [3] Department of Computer Science and Engineering, University of California San Diego, San Diego, CA, USA. [4] Department of Pediatrics, UC San Diego and Rady Children's Hospital, San Diego, CA, USA. [5] Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. [6] Sarafan ChEM-H, Stanford University, Stanford, CA, USA. [7] Department of Neurology and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA. [8] Medical Scientist Training Program, University of California San Diego, San Diego, CA, USA. [9] Biomedical Sciences Graduate Program, University of California San Diego, San Diego, CA, USA. [10] Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. [11] Salk Institute for Biological Studies, La Jolla, CA, USA. [12] Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. [13] Rady Children's Institute for Genomic Medicine, Rady Children's Hospital and Healthcare Center, San Diego, CA, USA. [14] Clinical Cooperation Unit Neuropathology (B300), German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 280, Heidelberg, Germany. [15] Papé Pediatric Research Institute, Department of Pediatrics and Knight Cancer Insitute, Oregon Health and Sciences University, Portland, OR, USA. [16] Division of Pathology, UC San Diego and Rady Children's Hospital, San Diego, CA, USA. [17] J. Craig Venter Institute, La Jolla, CA, USA. [18] Department of Pathology, University of California San Diego, San Diego, CA, USA. [19] Department of Pediatrics, University of California Irvine and Children's Hospital Orange County, Irvine, CA, USA. [20] Eli and Edythe Broad Institute of MIT and Harvard, Cambridge, MA, USA. [21] Department of Neurology, Boston Children's Hospital, Boston, MA, USA. [22] Harvard Medical School, Boston, MA, USA. [23] UPMC Hillman Cancer Center, Pittsburgh, PA, USA. [24] Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. [25] Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA. [26] Department of Genetics, Stanford University, Stanford, CA, USA. [27] Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. [28] Moores Cancer Center, University of California San Diego, San Diego, CA, USA. [29] Department of Medicine, University of California San Diego, San Diego, CA, USA. lchavez@sbpdiscovery.org. [30] Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, USA. lchavez@sbpdiscovery.org. [31] Rady Children's Institute for Genomic Medicine, Rady Children's Hospital and Healthcare Center, San Diego, CA, USA. lchavez@sbpdiscovery.org. [32] Moores Cancer Center, University of California San Diego, San Diego, CA, USA. lchavez@sbpdiscovery.org. [33]
DOI 10.1038/s41588-023-01551-3
PMID 37945900
发布时间 2024-03-27
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