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Vitamin B<sub>5</sub> supports MYC oncogenic metabolism and tumor progression in breast cancer.

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第一作者： Peter,Kreuzaler

第一单位： The Francis Crick Institute, London, UK. peter.kreuzaler@uni-koeln.de.;University of Cologne, Faculty of Medicine and University Hospital Cologne, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany. peter.kreuzaler@uni-koeln.de.

作者： Peter,Kreuzaler ^[1] ; Paolo,Inglese ^[2] ; Avinash,Ghanate ^[3] ; Ersa,Gjelaj ^[3] ; Vincen,Wu ^[2] ; Yulia,Panina ^[3] ; Andres,Mendez-Lucas ^[4] ; Catherine,MacLachlan ^[3] ; Neill,Patani ^[3] ; Catherine B,Hubert ^[3] ; Helen,Huang ^[2] ; Gina,Greenidge ^[5] ; Oscar M,Rueda ^[6] ; Adam J,Taylor ^[5] ; Evdoxia,Karali ^[7] ; Emine,Kazanc ^[7] ; Amy,Spicer ^[3] ; Alex,Dexter ^[5] ; Wei,Lin ^[3] ; Daria,Thompson ^[3] ; Mariana,Silva Dos Santos ^[3] ; Enrica,Calvani ^[3] ; Nathalie,Legrave ^[3] ; James K,Ellis ^[3] ; Wendy,Greenwood ^[8] ; Mary,Green ^[3] ; Emma,Nye ^[3] ; Emma,Still ^[3] ; CRUK Rosetta Grand Challenge Consortium ^[9] ; Simon,Barry ^[9] ; Richard J A,Goodwin ^[10] ; Alejandra,Bruna ^[8] ; Carlos,Caldas ^[3] ; James,MacRae ^[3] ; Luiz Pedro Sório,de Carvalho ^[7] ; George,Poulogiannis ^[5] ; Greg,McMahon ^[2] ; Zoltan,Takats ^[11] ; Josephine,Bunch ^[12] ; Mariia,Yuneva

作者单位： The Francis Crick Institute, London, UK. peter.kreuzaler@uni-koeln.de.;University of Cologne, Faculty of Medicine and University Hospital Cologne, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), Cologne, Germany. peter.kreuzaler@uni-koeln.de. ^[1] Faculty of Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, South Kensington Campus, London, UK. ^[2] The Francis Crick Institute, London, UK. ^[3] The Francis Crick Institute, London, UK.;Department of Physiological Sciences, University of Barcelona, Barcelona, Spain. ^[4] The National Physical Laboratory, Teddington, UK. ^[5] University of Cambridge, MRC Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, UK. ^[6] Signalling and Cancer Metabolism Team, Division of Cancer Biology, The Institute of Cancer Research, London, UK. ^[7] University of Cambridge, Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. ^[8] Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK. ^[9] Modelling of Paediatric Cancer Evolution, Centre for Paediatric Oncology, Experimental Medicine, Centre for Cancer Evolution: Molecular Pathology Division, The Institute of Cancer Research, Belmont, Sutton, London, UK. ^[10] The National Physical Laboratory, Teddington, UK.;The Rosalind Franklin Institute, Harwell Campus, Didcot, UK. ^[11] The Francis Crick Institute, London, UK. Mariia.Yuneva@crick.ac.uk. ^[12]

医学主题词人类(Humans);小鼠(Mice);动物(Animals);女(雌)性(Female);乳腺肿瘤(Breast Neoplasms);泛酸(Pantothenic Acid);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);转录因子(Transcription Factors);维生素类(Vitamins)

DOI 10.1038/s42255-023-00915-7

PMID 37946084

发布时间 2025-12-03

基金项目

FC001223/WT_/Wellcome Trust/United Kingdom MC_UU_00002/16/MRC_/Medical Research Council/United Kingdom

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2023年5卷11期

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Vitamin B<sub>5</sub> supports MYC oncogenic metabolism and tumor progression in breast cancer.

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Vitamin B<sub>5</sub> supports MYC oncogenic metabolism and tumor progression in breast cancer.

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