Senescence-Targeted and NAD<sup>+</sup>-Dependent SIRT1-Activated Nanoplatform to Counteract Stem Cell Senescence for Promoting Aged Bone Regeneration.

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第一作者： Ying,Wang

第一单位： Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.

作者： Ying,Wang ^[1] ; Fangru,Xie ^[1] ; Zirui,He ^[1] ; Lingbin,Che ^[2] ; Xi,Chen ^[1] ; Yuan,Yuan ^[1] ; Changsheng,Liu ^[1]

作者单位： Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomaterials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China. ^[1] Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, P. R. China. ^[2]

关键词 NAD+‐dependent SIRT1‐activated nanoplatforms aged bone healing multi‐delivery senescence‐specific biomarker validation stem cell senescence delay

主题词老年人(Aged);人类(Humans);抗衰老酶1(Sirtuin 1);NAD(NAD);骨生成(Osteogenesis);骨再生(Bone Regeneration)

DOI 10.1002/smll.202304433

PMID 37948437

发布时间 2024-03-25

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