Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.

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第一作者： Rie,Nishikawa-Shimono

第一单位： Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.

作者： Rie,Nishikawa-Shimono ^[1] ; Motoi,Kuwabara ^[1] ; Sho,Fujisaki ^[1] ; Daisuke,Matsuda ^[2] ; Mayumi,Endo ^[3] ; Masafumi,Kamitani ^[3] ; Aya,Futamura ^[1] ; Yusaku,Nomura ^[1] ; Toru,Yamaguchi-Sasaki ^[1] ; Tetsuya,Yabuuchi ^[1] ; Chitose,Yamaguchi ^[1] ; Nozomi,Tanaka-Yamamoto ^[1] ; Shunya,Satake ^[1] ; Kumi,Abe-Sato ^[1] ; Kosuke,Funayama ^[1] ; Mayumi,Sakata ^[3] ; Shinji,Takahashi ^[4] ; Koga,Hirano ^[4] ; Takuya,Fukunaga ^[3] ; Yoriko,Uozumi ^[3] ; Sayaka,Kato ^[3] ; Yunoshin,Tamura ^[3] ; Tomoaki,Nakamori ^[3] ; Masashi,Mima ^[3] ; Chiemi,Mishima-Tsumagari ^[3] ; Dai,Nozawa ^[1] ; Yudai,Imai ^[1] ; Taiji,Asami ^[5]

作者单位： Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. ^[1] Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. Electronic address: d-matsuda@taisho.co.jp. ^[2] Discovery Technologies Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. ^[3] Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. ^[4] Medicinal Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. Electronic address: ta-asami@taisho.co.jp. ^[5]

关键词 Fragile X syndrome Indole derivatives Inhibitor of proMMP-9 activation Matrix metalloproteinase-9 Structure-based drug design

主题词基质金属蛋白酶9(Matrix Metalloproteinase 9);酶前体(Enzyme Precursors);细胞外基质(Extracellular Matrix);吲哚类(Indoles);金属内肽酶类(Metalloendopeptidases)

DOI 10.1016/j.bmcl.2023.129541

PMID 37952596

发布时间 2024-01-04

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