Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression.

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第一作者： Munishikha,Kalia

第一单位： Department of Biostatistics and Health Informatics, King's College London, London, UK.

作者： Munishikha,Kalia ^[1] ; Mattia,Miotto ^[2] ; Deborah,Ness ^[3] ; Sarah,Opie-Martin ^[1] ; Thomas P,Spargo ^[2] ; Lorenzo,Di Rienzo ^[2] ; Tommaso,Biagini ^[1] ; Francesco,Petrizzelli ^[2] ; Ahmad,Al Khleifat ^[3] ; Renata,Kabiljo ^[4] ; Project MinE ALS Sequencing Consortium ^[4] ; SOD1-ALS clinical and genetic data collection group ^[2] ; Tommaso,Mazza ^[1] ; Giancarlo,Ruocco ^[2] ; Edoardo,Milanetti ^[4] ; Richard Jb,Dobson ^[3] ; Ammar,Al-Chalabi ^[5] ; Alfredo,Iacoangeli ^[3]

作者单位： Department of Biostatistics and Health Informatics, King's College London, London, UK. ^[1] Department of Basic and Clinical Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK. ^[2] Center for Life Nano & Neuro Science, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161, Rome, Italy. ^[3] Bioinformatics Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy. ^[4] Department of Physics, Sapienza University, Piazzale Aldo Moro 5, 00185, Rome, Italy. ^[5] Institute of Health Informatics, University College London, London, UK. ^[6] National Institute for Health Research Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust King's College London, London, United Kingdom. ^[7] Clinical Neurosciences, King's College Hospital, Denmark Hill, London, UK. ^[8]

关键词 Amyotrophic lateral sclerosis Diseaseassociated SOD1 mutations Molecular dynamics (MD) simulations Performed principal component analysis Superoxide Dismutase type 1 (SOD1)Survival analysis

DOI 10.1016/j.csbj.2023.09.016

PMID 37954145

发布时间 2023-11-14

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Computational and structural biotechnology journal

2023年21卷

5296-5308页

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Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression.

Computational and structural biotechnology journal

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Computational and structural biotechnology journal

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Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression.

Computational and structural biotechnology journal

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Computational and structural biotechnology journal

相关期刊

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