首页> CPT: pharmacometrics & systems pharmacology> A model-based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno-oncology.

A model-based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno-oncology.

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第一作者： Javier,Sánchez

第一单位： Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.;Department of Pharmacy, Uppsala University, Uppsala, Sweden.

作者： Javier,Sánchez ^[1] ; Christina,Claus ^[2] ; Rosmarie,Albrecht ^[2] ; Brenda C,Gaillard ^[2] ; Joana,Marinho ^[2] ; Christine,McIntyre ^[3] ; Tamara,Tanos ^[4] ; Axel,Boehnke ^[4] ; Lena E,Friberg ^[5] ; Siv,Jönsson ^[5] ; Nicolas,Frances ^[4]

作者单位： Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland.;Department of Pharmacy, Uppsala University, Uppsala, Sweden. ^[1] Roche Pharma Research and Early Development (pRED), Roche Innovation Center Zurich, Schlieren, Switzerland. ^[2] Roche Pharma Research and Early Development, Roche Innovation Center Welwyn, Welwyn Garden City, UK. ^[3] Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, Basel, Switzerland. ^[4] Department of Pharmacy, Uppsala University, Uppsala, Sweden. ^[5]

医学主题词人类(Humans);抗体, 双特异性(Antibodies, Bispecific);肿瘤(Neoplasms);T淋巴细胞(T-Lymphocytes)

DOI 10.1002/psp4.13065

PMID 37964753

发布时间 2024-05-22

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CPT: pharmacometrics & systems pharmacology

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2023年12卷11期

1804-1818页

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2023年12卷11期

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A model-based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno-oncology.

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A model-based approach leveraging in vitro data to support dose selection from the outset: A framework for bispecific antibodies in immuno-oncology.

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