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PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice.

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第一作者： Antonietta,Vilella

第一单位： Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy. Electronic address: antonietta.vilella@unimore.it.

作者： Antonietta,Vilella ^[1] ; Martina,Bodria ^[2] ; Bianca,Papotti ^[3] ; Ilaria,Zanotti ^[3] ; Francesca,Zimetti ^[4] ; Giulia,Remaggi ^[3] ; Lisa,Elviri ^[3] ; Francesco,Potì ^[5] ; Nicola,Ferri ^[6] ; Maria Giovanna,Lupo ^[7] ; Giovanni,Panighel ^[3] ; Eleonora,Daini ^[2] ; Eleonora,Vandini ^[3] ; Michele,Zoli ^[2] ; Daniela,Giuliani ^[2] ; Franco,Bernini ^[3]

作者单位： Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy. Electronic address: antonietta.vilella@unimore.it. ^[1] Department of Biomedical, Metabolic and Neural Sciences, Center for Neuroscience and Neurotechnology, University of Modena and Reggio Emilia, 41125 Modena, Italy. ^[2] Department of Food and Drug, University of Parma, 43124 Parma, Italy. ^[3] Department of Food and Drug, University of Parma, 43124 Parma, Italy. Electronic address: francesca.zimetti@unipr.it. ^[4] Department of Medicine and Surgery, Unit of Neurosciences, University of Parma, 43121, Parma, Italy. ^[5] Department of Medicine, University of Padova, 35129, Padova, Italy; Veneto Institute of Molecular Medicine (VIMM), 35129, Padova, Italy. ^[6] Department of Medicine, University of Padova, 35129, Padova, Italy. ^[7]

关键词 5XFAD mice Alzheimer’s disease Amyloidosis Cognitive dysfunction Microglia PCSK9