AZD7648, a DNA-PKcs inhibitor, overcomes radioresistance in Hep3B xenografts and cells under tumor hypoxia.

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作者： Jimin,Ha ^[1] ; Mijeong,Park ^[2] ; Yuri,Lee ^[1] ; Sang Hyun,Choi ^[1] ; Byoung Soo,Kim ^[2] ; Hunjoo,Ha ^[3] ; Youn Kyoung,Jeong ^[4]

作者单位： Radiological and Medical Support Center, Korea Institute of Radiological and Medical Sciences (KIRAMS) Seoul, Republic of Korea. ^[1] Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University Seoul, Republic of Korea. ^[2] Research Team of Medical Physics and Engineering, Korea Institute of Radiological and Medical Sciences Seoul, Republic of Korea. ^[3] Division of Applied RI, Korea Institute of Radiological and Medical Sciences Seoul, Republic of Korea. ^[4]

关键词 AZD7648 HIF-1α cancer hypoxia ionizing radiation radioresistance radiosensitizer xenograft mouse

PMID 37970336

发布时间 2024-02-12

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准确一般字义偏差语意偏离译文作用小提交