Cryo-EM of Aβ fibrils from mouse models find tg-APP<sub>ArcSwe</sub> fibrils resemble those found in patients with sporadic Alzheimer's disease.

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第一作者： Mara,Zielinski

第一单位： Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany.

作者： Mara,Zielinski ^[1] ; Fernanda S,Peralta Reyes ^[2] ; Lothar,Gremer ^[3] ; Sarah,Schemmert ^[4] ; Benedikt,Frieg ^[5] ; Luisa U,Schäfer ^[6] ; Antje,Willuweit ^[1] ; Lili,Donner ^[1] ; Margitta,Elvers ^[2] ; Lars N G,Nilsson ^[1] ; Stina,Syvänen ^[2] ; Dag,Sehlin ^[7] ; Martin,Ingelsson ^[8] ; Dieter,Willbold ^[9] ; Gunnar F,Schröder ^[9]

作者单位： Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany. ^[1] JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany. ^[2] Institut für Physikalische Biologie, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. ^[3] Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany. l.gremer@fz-juelich.de. ^[4] JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany. l.gremer@fz-juelich.de. ^[5] Institut für Physikalische Biologie, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. l.gremer@fz-juelich.de. ^[6] Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany. ^[7] Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, Jülich, Germany. ^[8] Department of Vascular and Endovascular Surgery, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf, Germany. ^[9] Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway. ^[10] Department of Public Health and Caring Sciences, Molecular Geriatrics, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden. ^[11] Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada. ^[12] Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada. ^[13] Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany. D.Willbold@fz-juelich.de. ^[14] JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany. D.Willbold@fz-juelich.de. ^[15] Institut für Physikalische Biologie, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. D.Willbold@fz-juelich.de. ^[16] Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, Jülich, Germany. gu.schroeder@fz-juelich.de. ^[17] JuStruct, Jülich Center for Structural Biology, Forschungszentrum Jülich, Jülich, Germany. gu.schroeder@fz-juelich.de. ^[18] Physics Department, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. gu.schroeder@fz-juelich.de. ^[19]