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CD97 negatively regulates the innate immune response against RNA viruses by promoting RNF125-mediated RIG-I degradation.

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第一作者： Huasong,Chang

第一单位： Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, 250014, China.

作者： Huasong,Chang ^[1] ; Peili,Hou ^[2] ; Xuefeng,Wang ^[3] ; Aibiao,Xiang ^[1] ; Hao,Wu ^[1] ; Wenjing,Qi ^[1] ; Rukun,Yang ^[1] ; Xue,Wang ^[1] ; Xingyu,Li ^[1] ; Wenqi,He ^[4] ; Guimin,Zhao ^[1] ; Weiyang,Sun ^[3] ; Tiecheng,Wang ^[3] ; Daniel Chang,He ^[5] ; Hongmei,Wang ^[6] ; Yuwei,Gao ^[7] ; Hongbin,He ^[8]

作者单位： Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, 250014, China. ^[1] Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, 250014, China.;Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, 271018, China. ^[2] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, 130122, China. ^[3] Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, Jilin, 130062, China. ^[4] The College of Arts and Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. ^[5] Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, 250014, China. hongmeiwang@sdnu.edu.cn. ^[6] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin, 130122, China. yuwei0901@outlook.com. ^[7] Ruminant Diseases Research Center, College of Life Sciences, Shandong Normal University, Jinan, Shandong, 250014, China. hongbinhe@sdnu.edu.cn.;Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, Taian, Shandong, 271018, China. hongbinhe@sdnu.edu.cn. ^[8]

关键词 CD97 IFN-I RIG-I RNA virus Ubiquitination