Methyl 4-pyridyl ketone thiosemicarbazone (4-PT) as an effective and safe inhibitor of mushroom tyrosinase and antibrowning agent.

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作者： Nur Amanina,Hassanuddin ^[1] ; Erna,Normaya ^[2] ; Hakimah,Ismail ^[1] ; Anwar,Iqbal ^[3] ; Mohd Bijarimi Mat,Piah ^[4] ; Shafida,Abd Hamid ^[5] ; Mohammad Norazmi,Ahmad ^[6]

作者单位： Experimental and Theoretical Research Lab (ETRL), Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, Pahang, Malaysia. ^[1] Experimental and Theoretical Research Lab (ETRL), Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, Pahang, Malaysia; Sustainable Nanotechnology and Computational Modelling (SuNCoM) Research Group, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia. ^[2] School of Chemical Science, Universiti Sains Malaysia, 11800 Penang, Malaysia. ^[3] Faculty of Chemical & Natural Resources Engineering, Universiti Malaysia Pahang, Kuantan, Malaysia. ^[4] Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, Pahang, Malaysia. ^[5] Experimental and Theoretical Research Lab (ETRL), Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, Pahang, Malaysia; Sustainable Nanotechnology and Computational Modelling (SuNCoM) Research Group, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia. Electronic address: mnorazmi85@gmail.com. ^[6]

关键词 Antibrowning agent Density functional theory (DFT)Spectroscopy Thiosemicarbazone Tyrosinase inhibitor

主题词一元酚单氧酶(Monophenol Monooxygenase);伞菌目(Agaricales);缩氨硫脲类(Thiosemicarbazones);磁共振波谱学(Magnetic Resonance Spectroscopy);酮类(Ketones);酶抑制剂(Enzyme Inhibitors)

DOI 10.1016/j.ijbiomac.2023.128229

PMID 37981274

发布时间 2024-01-10

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