Novel <i>N</i>-Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations.

导出 OA

翻译打印收藏纠错

作者： Hesham,Haffez ^[1] ; Nosaiba A,Elsayed ^[2] ; Marwa F,Ahmed ^[3] ; Samar S,Fatahala ^[3] ; Eman F,Khaleel ^[4] ; Rehab Mustafa,Badi ^[5] ; Eslam B,Elkaeed ^[5] ; Mahmoud A,El Hassab ^[6] ; Sherif F,Hammad ^[7] ; Wagdy M,Eldehna ^[3] ; Nicolas,Masurier ^[8] ; Radwan,El-Haggar ^[9]

作者单位： Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Cairo, Ain Helwan, Egypt. ^[1] Center of Scientific Excellence "Helwan Structural Biology Research, (HSBR)", Helwan University, Cairo, Egypt. ^[2] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Ain Helwan, Egypt. ^[3] Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt. ^[4] Department of Medical Physiology, College of Medicine, King Khalid University, Asir, Saudi Arabia. ^[5] Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia. ^[6] Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt. ^[7] Medicinal Chemistry Department, PharmD Program, Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City, Egypt Alexandria. ^[8] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt. ^[9] Institut des Biomolécules Max Mousseron (IBMM), UMR 5247, CNRS, Université de Montpellier, ENSCM, Montpellier, France. ^[10]

关键词 VEGFR-2 anticancer agents apoptosis induction molecular docking

主题词分子动力学模拟(Molecular Dynamics Simulation);查耳酮类(Chalcones);血管内皮生长因子受体2(Vascular Endothelial Growth Factor Receptor-2);苯胺化合物(Aniline Compounds);查耳酮(Chalcone)

DOI 10.1080/14756366.2023.2278022

PMID 37982203

发布时间 2024-04-11

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交