Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M.

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第一作者： Hao,Liu

第一单位： Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China; Department of Pharmacology, Chongqing Medical University, Chongqing, China.

作者： Hao,Liu ^[1] ; Nana,Li ^[1] ; Ge,Kuang ^[1] ; Xia,Gong ^[2] ; Ting,Wang ^[3] ; Jun,Hu ^[1] ; Hui,Du ^[1] ; Minxuan,Zhong ^[4] ; Jiashi,Guo ^[1] ; Yao,Xie ^[1] ; Yang,Xiang ^[1] ; Shengwang,Wu ^[5] ; Yiling,Yuan ^[6] ; Xinru,Yin ^[7] ; Jingyuan,Wan ^[8] ; Ke,Li ^[9]

作者单位： Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China; Department of Pharmacology, Chongqing Medical University, Chongqing, China. ^[1] Department of Anatomy, Chongqing Medical University, Chongqing, China. ^[2] Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. ^[3] Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China. ^[4] Department of Hematology, Xinqiao Hospital, Army Medical University, Chongqing, China. ^[5] Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. ^[6] Department of Gastroenterology, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, China. ^[7] Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China; Department of Pharmacology, Chongqing Medical University, Chongqing, China. Electronic address: jywan@cqmu.edu.cn. ^[8] Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Medical University, Chongqing, China; Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: li.ke@hospital.cqmu.edu.cn. ^[9]

关键词 IRAK-M Non-alcoholic steatohepatitis Protectin D1 Toll like receptor 4 n-3 polyunsaturated fatty acid