Anti-LGALS3BP antibody-drug conjugate treatment induces durable and potent antitumor response in a preclinical model of adenoid cystic carcinoma.

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作者： Emily,Capone ^[1] ; Vittoria,Perrotti ^[2] ; Ilaria,Cela ^[1] ; Rossano,Lattanzio ^[1] ; Lucrezia,Togni ^[3] ; Corrado,Rubini ^[3] ; Vito Carlo Alberto,Caponio ^[4] ; Lorenzo,Lo Muzio ^[4] ; Martina,Colasante ^[5] ; Francesco,Giansanti ^[5] ; Rodolfo,Ippoliti ^[5] ; Stefano,Iacobelli ^[6] ; Michael J,Wick ^[7] ; Nicole,Spardy Burr ^[8] ; Gianluca,Sala ^[9]

作者单位： Department of Innovative Technologies in Medicine & Dentistry, University "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy; Center for Advanced Studies and Technology (CAST), University "G.D'Annunzio" of Chieti-Pescara, Chieti, Italy. ^[1] Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, Chieti, Italy; UdA-TechLab, Research Center, University "G. d'Annunzio" of Chieti-Pescara, 66100 Chieti, Italy. ^[2] Department of Biomedical, Sciences and Public Health, Marche Polytechnic University, Ancona, Italy. ^[3] Department of Clinical and Experimental Medicine, Foggia University, Foggia, Italy. ^[4] Department of Life, Health and Environmental Sciences, University of L'Aquila, Coppito, Italy. ^[5] MediaPharma s.r.l., Via Colonnetta 50/A, Chieti, Italy. ^[6] XenoSTART, San Antonio, TX, USA. ^[7] Adenoid Cystic Carcinoma Research Foundation (ACCRF), Needham, MA, USA. ^[8] Department of Innovative Technologies in Medicine & Dentistry, University "G. D'Annunzio" of Chieti-Pescara, Chieti, Italy; Center for Advanced Studies and Technology (CAST), University "G.D'Annunzio" of Chieti-Pescara, Chieti, Italy. Electronic address: g.sala@unich.it. ^[9]

关键词 Adenoid cystic carcinoma Antibody-drug conjugate Immunotherapy LGALS3BP Oral cancer Targeted therapy