The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture.

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作者： Yongting,Luo ^[1] ; Junjie,Luo ^[1] ; Peng,An ^[1] ; Yuanfei,Zhao ^[2] ; Wenting,Zhao ^[3] ; Zhou,Fang ^[4] ; Yi,Xia ^[5] ; Lin,Zhu ^[1] ; Teng,Xu ^[2] ; Xu,Zhang ^[3] ; Shuaishuai,Zhou ^[4] ; Mingyan,Yang ^[5] ; Jiayao,Li ^[1] ; Junming,Zhu ^[1] ; Yongmin,Liu ^[1] ; Haiyang,Li ^[1] ; Ming,Gong ^[1] ; Yuyong,Liu ^[6] ; Jie,Han ^[6] ; Huiyuan,Guo ^[2] ; Hongjia,Zhang ^[3] ; Wenjian,Jiang ^[4] ; Fazheng,Ren ^[5]

作者单位： Department of Nutrition and Health, Beijing Advanced Innovation Center for Food Nutrition and Human Health, No. 10 Tianxiu Road, Haidian District, China Agricultural University, Beijing 100193, China. ^[1] Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China. ^[2] Beijing Institute of Heart, Lung and Blood Vessel Diseases, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China. ^[3] Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100069, China. ^[4] Beijing Lab for Cardiovascular Precision Medicine, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100069, China. ^[5] Analytical Biosciences Limited, Beijing 100084, China. ^[6]

关键词 AP-1 transcriptional complex Aortic dissection OXPHOS Phenotypic switch TNF signalling scRNA-seq