Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management.

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作者： Andrea I,d'Aquino ^[1] ; Caitlin L,Maikawa ^[2] ; Leslee T,Nguyen ^[3] ; Katie,Lu ^[4] ; Ian A,Hall ^[2] ; Carolyn K,Jons ^[1] ; Catherine M,Kasse ^[1] ; Jerry,Yan ^[2] ; Alexander N,Prossnitz ^[1] ; Enmian,Chang ^[1] ; Sam W,Baker ^[5] ; Lars,Hovgaard ^[6] ; Dorte B,Steensgaard ^[6] ; Hanne B,Andersen ^[6] ; Lotte,Simonsen ^[7] ; Eric A,Appel ^[8]

作者单位： Department of Materials Science & Engineering, Stanford University, Stanford, CA 94025, USA. ^[1] Department of Bioengineering, Stanford University, Stanford, CA 94305, USA. ^[2] Department of Biochemistry, Stanford University, Palo Alto, CA 94305, USA. ^[3] Department of Biology, Stanford University, Stanford, CA 94305, USA. ^[4] Department of Comparative Medicine, Stanford University, Palo Alto, CA 94305, USA. ^[5] Department of Biophysics and Formulations, Global Research Technologies, Novo Nordisk Park, 2760 Maaloev, Denmark. ^[6] Department of Obesity Research, Global Drug Discovery, Novo Nordisk Park, 2760 Maaloev, Denmark. ^[7] Department of Materials Science & Engineering, Stanford University, Stanford, CA 94025, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Department of Pediatrics (Endocrinology), Stanford University, Stanford, CA 94305, USA; Woods Institute for the Environment, Stanford University, Stanford, CA 94305, USA. Electronic address: eappel@stanford.edu. ^[8]

关键词 GLP-1 RA diabetes drug delivery supramolecular hydrogel

主题词人类(Humans);动物(Animals);大鼠(Rats);糖尿病, 2型(Diabetes Mellitus, Type 2);降血糖药(Hypoglycemic Agents);水凝胶类(Hydrogels);生物模拟学(Biomimetics);胰高血糖素样肽1(Glucagon-Like Peptide 1)

DOI 10.1016/j.xcrm.2023.101292

PMID 37992687

发布时间 2024-05-18

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Cell reports. Medicine

2023年4卷11期

101292页

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Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management.

Cell reports. Medicine

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Use of a biomimetic hydrogel depot technology for sustained delivery of GLP-1 receptor agonists reduces burden of diabetes management.

Cell reports. Medicine

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Cell reports. Medicine

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