New spiro-indeno[1,2-<i>b</i>]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights.

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作者： Assem,Barakat ^[1] ; Saeed,Alshahrani ^[1] ; Abdullah Mohammed,Al-Majid ^[1] ; Abdullah Saleh,Alamary ^[1] ; Matti,Haukka ^[2] ; Marwa M,Abu-Serie ^[3] ; Luis R,Domingo ^[4] ; Sajda,Ashraf ^[5] ; Zaheer,Ul-Haq ^[5] ; Mohamed S,Nafie ^[6] ; Mohamed,Teleb ^[7]

作者单位： Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. ^[1] Department of Chemistry, University of Jyväskylä, Jyväskylä, Finland. ^[2] Medical Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications (SRTA-City), Egypt. ^[3] Department of Organic Chemistry, University of Valencia, Burjassot, Valencia, Spain. ^[4] Dr. Panjwani Center for Molecular medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan. ^[5] Department of Chemistry, College of Sciences, University of Sharjah, Sharjah, UAE. ^[6] Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt. ^[7] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt. ^[8]

关键词 CDK2 Lung Cancer Molecular Electron Density Theory Molecular dynamics Spiro-indeno[12-b]quinoxalines