An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds.
作者:
主题词
动物(Animals);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);抗惊厥药(Anticonvulsants);斑马鱼(Zebrafish);小鼠(Mice);神经元(Neurons);药物评价, 临床前(Drug Evaluation, Preclinical);发作(Seizures);高通量筛选分析(High-Throughput Screening Assays);疾病模型, 动物(Disease Models, Animal);癫痫(Epilepsy);细胞, 培养的(Cells, Cultured);联苯化合物(Biphenyl Compounds);香豆素类(Coumarins);木酚素类(Lignans)
DOI
10.1016/j.jare.2023.11.022
PMID
37995945
发布时间
2024-10-12
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Journal of advanced research
2024年64卷
249-262页
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