Epigenetic downregulation of O<sup>6</sup>-methylguanine-DNA methyltransferase contributes to chronic hexavalent chromium exposure-caused genotoxic effect and cell transformation.

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作者： Zhishan,Wang ^[1] ; Zulong,Liu ^[2] ; Po-Shun,Wang ^[2] ; Hsuan-Pei,Lin ^[3] ; Matthew,Rea ^[4] ; Kazuya,Kondo ^[5] ; Chengfeng,Yang ^[6]

作者单位： Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY 11794, USA. Electronic address: Zhishan.wang@stonybrook.edu. ^[1] Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA. ^[2] Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA. ^[3] Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA. ^[4] Department of Oncological Medical Services, Graduate School of Biomedical Sciences, Tokushima University Graduate School, Tokushima City 770-8509, Japan. ^[5] Stony Brook Cancer Center, Stony Brook University, Lauterbur Drive, Stony Brook, NY 11794, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, 101 Nicolls Road, Stony Brook, NY 11794, USA. ^[6]

关键词 DNA methylation Epigenetic toxicity Hexavalent chromium [Cr(VI)]Histone H3 repressive modification MGMT O(6)-methylguanine (O(6)-MeG)