Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease.

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作者： Xiaowen,Chen ^[1] ; Jing,Xiao ^[2] ; Danping,Tao ^[3] ; Yunyi,Liang ^[2] ; Sijia,Chen ^[4] ; Lingyu,Shen ^[2] ; Shuting,Li ^[2] ; Zerong,Zheng ^[2] ; Yao,Zeng ^[2] ; Congwei,Luo ^[2] ; Fenfen,Peng ^[5] ; Haibo,Long ^[6]

作者单位： Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: 573281676@qq.com. ^[1] Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ^[2] Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Department of Gerontology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. ^[3] Department of Nephrology and Rheumatology, The First Hospital of Changsha, Changsha, China. ^[4] Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: doctorpff@163.com. ^[5] Department of Nephrology, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: longhb1966@163.com. ^[6]

关键词 MTDH PKA PKM2 Podocyte injury Proteinuria β-catenin

主题词人类(Humans);小鼠(Mice);动物(Animals);足细胞(Podocytes);β连环素(beta Catenin);环AMP依赖性蛋白激酶类(Cyclic AMP-Dependent Protein Kinases);转录因子(Transcription Factors);蛋白尿(Proteinuria);糖尿病肾病(Diabetic Nephropathies);肾功能不全, 慢性(Renal Insufficiency, Chronic);膜蛋白质类(Membrane Proteins);RNA结合蛋白质类(RNA-Binding Proteins)

DOI 10.1016/j.trsl.2023.11.006

PMID 37995969

发布时间 2024-03-12

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Translational research

2024年266卷

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Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease.

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Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease.

Translational research

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Translational research

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