Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8<sup>+</sup> T cells.

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第一作者： Weizhi,He

第一单位： Institute for Regenerative Medicine, Ji'an Hospital, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University School of Medicine, Shanghai, China.

作者： Weizhi,He ^[1] ; Xicheng,Wang ^[2] ; Miaomiao,Chen ^[3] ; Chong,Li ^[1] ; Wenjian,Chen ^[2] ; Lili,Pan ^[1] ; Yangyang,Cui ^[2] ; Zhao,Yu ^[4] ; Guoxiu,Wu ^[1] ; Yang,Yang ^[2] ; Mingyang,Xu ^[1] ; Zhaoxuan,Dong ^[2] ; Keming,Ma ^[1] ; Jinghan,Wang ^[5] ; Zhiying,He ^[1]

作者单位： Institute for Regenerative Medicine, Ji'an Hospital, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University School of Medicine, Shanghai, China. ^[1] Shanghai Engineering Research Center of Stem Cells Translational Medicine, Shanghai, China. ^[2] Fudan University Shanghai Cancer Center, International Co-Laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Shanghai Medical College of Fudan University, Institutes of Biomedical Sciences, Shanghai Key Laboratory of Medical Epigenetics, Shanghai, China. ^[3] Zhoupu Community Health Service Center of Pudong New Area, Shanghai, China. ^[4] Postgraduate Training Base of Shanghai East Hospital, Jinzhou Medical University, Jinzhou, Liaoning, China. ^[5] Department of Hepatobiliary and Pancreatic Surgery, Shanghai East Hospital, Tongji University, Shanghai, China. ^[6]

关键词 CD8+ T cells Cyp26a1 atRA hepatocellular carcinoma metformin

主题词人类(Humans);动物(Animals);小鼠(Mice);癌, 肝细胞(Carcinoma, Hepatocellular);肝肿瘤(Liver Neoplasms);二甲双胍(Metformin);减量调节(Down-Regulation);AMP活化蛋白激酶类(AMP-Activated Protein Kinases);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);维甲酸(Tretinoin);RNA(RNA)

DOI 10.1002/ctm2.1465

PMID 37997519

发布时间 2024-04-17

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Clinical and translational medicine

2023年13卷11期

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Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8<sup>+</sup> T cells.

Clinical and translational medicine

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Clinical and translational medicine

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Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8<sup>+</sup> T cells.

Clinical and translational medicine

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Clinical and translational medicine

相关期刊

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