The variability in CYP3A4 activity determines the metabolic kinetic characteristics of ketamine.

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作者： Mengfang,Li ^[1] ; Qingqing,Li ^[2] ; Dan,Lin ^[3] ; Xiang,Zheng ^[2] ; Lehao,Jin ^[2] ; Jianping,Cai ^[4] ; Guoxin,Hu ^[5] ; Jianchang,Qian ^[6]

作者单位： Department of Emergency Medicine, The First Afﬁliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. ^[1] Institute of Molecular Toxicology and Pharmacology, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. ^[2] Wenzhou Medical University Forensic Center, Wenzhou, Zhejiang, China. ^[3] The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China. Electronic address: caijp61@vip.sina.com. ^[4] Institute of Molecular Toxicology and Pharmacology, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China; Wenzhou Medical University Forensic Center, Wenzhou, Zhejiang, China. Electronic address: hgx@wmu.edu.cn. ^[5] Institute of Molecular Toxicology and Pharmacology, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: qianjc@wmu.edu.cn. ^[6]

关键词 CYP3A4 Gene polymorphism Ketamine Kinetics Voriconazole