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A binary system based DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells.

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第一作者： Tong,Li

第一单位： NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China.

作者： Tong,Li ^[1] ; Mengxu,Sun ^[1] ; Suping,Xia ^[1] ; Ting,Huang ^[1] ; Rong-Tian,Li ^[2] ; Chunrong,Li ^[3] ; Zong,Dai ^[4] ; Jin-Xiang,Chen ^[5] ; Jun,Chen ^[6] ; Nuan,Jia ^[7]

作者单位： NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China. ^[1] Southern University of Science and Technology Hospital, Shenzhen, 518055, PR China. ^[2] Qiannan Medical College for Nationalities, Duyun, 558000, PR China. ^[3] Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-Sen University, Shenzhen, 518107, PR China. ^[4] NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China. Electronic address: jxchen@smu.edu.cn. ^[5] NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China; Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Qingdao University of Science and Technology, Qingdao, 266042, PR China. Electronic address: chenj258@smu.edu.cn. ^[6] Southern University of Science and Technology Hospital, Shenzhen, 518055, PR China. Electronic address: nkdyyyjk@163.com. ^[7]

关键词 Binary probes DNA tetrahedron Fluorogenic RNA aptamers mRNA imaging

医学主题词 RNA, 信使(RNA, Messenger);适体, 核苷(Aptamers, Nucleotide);荧光染料(Fluorescent Dyes);DNA(DNA)

DOI 10.1016/j.talanta.2023.125465

PMID 38008022

发布时间 2024-01-16

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