Mechanisms of synthetic lethality between BRCA1/2 and 53BP1 deficiencies and DNA polymerase theta targeting.

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第一作者： George E,Ronson

第一单位： Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

作者： George E,Ronson ^[1] ; Katarzyna,Starowicz ^[1] ; Elizabeth J,Anthony ^[2] ; Ann Liza,Piberger ^[1] ; Lucy C,Clarke ^[1] ; Alexander J,Garvin ^[1] ; Andrew D,Beggs ^[3] ; Celina M,Whalley ^[1] ; Matthew J,Edmonds ^[4] ; James F J,Beesley ^[1] ; Joanna R,Morris ^[5]

作者单位： Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. ^[1] Adthera Bio, Lyndon House, 62 Hagley Road, Birmingham, B16 8PE, UK. ^[2] West Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Mindelsohn Way, Birmingham, B15 2TG, UK. ^[3] University of Leeds, Leeds, UK. ^[4] Genomics Birmingham, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. ^[5] Certara Insight, Danebrook Court, Oxford Office Village, Kidlington, Oxfordshire, OX5 1LQ, UK. ^[6] Birmingham Centre for Genome Biology and Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK. j.morris.3@bham.ac.uk. ^[7]

主题词 BRCA1蛋白质(BRCA1 Protein);BRCA2蛋白质(BRCA2 Protein);DNA修复(DNA Repair)

DOI 10.1038/s41467-023-43677-2

PMID 38030626

发布时间 2024-03-13

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