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Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.

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第一作者： Steffen S,Docken

第一单位： Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

作者： Steffen S,Docken ^[1] ; Kevin,McCormick ^[2] ; M Betina,Pampena ^[3] ; Sadia,Samer ^[4] ; Emily,Lindemuth ^[5] ; Mykola,Pinkevych ^[1] ; Elise G,Viox ^[4] ; Yuhuang,Wu ^[1] ; Timothy E,Schlub ^[6] ; Deborah,Cromer ^[1] ; Brandon F,Keele ^[7] ; Mirko,Paiardini ^[8] ; Michael R,Betts ^[3] ; Katharine J,Bar ^[5] ; Miles P,Davenport ^[1]

作者单位： Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia. ^[1] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. ^[2] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.;Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. ^[3] Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America. ^[4] Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. ^[5] Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. ^[6] AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America. ^[7] Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.;Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, United States of America. ^[8]

医学主题词动物(Animals);猴获得性免疫缺陷综合征(Simian Acquired Immunodeficiency Syndrome);猕猴(Macaca mulatta);病毒复制(Virus Replication);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);HIV感染(HIV Infections);表位(Epitopes);病毒载量(Viral Load);抗逆转录病毒药(Anti-Retroviral Agents)

DOI 10.1371/journal.ppat.1011755

PMID 38032851

发布时间 2026-01-08

基金项目

75N91019D00024/CA/NCI NIH HHS/United States P51 OD011132/OD/NIH HHS/United States UM1 AI164570/AI/NIAID NIH HHS/United States HHSN261201500003C/CA/NCI NIH HHS/United States R01 MH128155/MH/NIMH NIH HHS/United States P30 AI045008/AI/NIAID NIH HHS/United States R01 AI162646/AI/NIAID NIH HHS/United States U01 AI169767/AI/NIAID NIH HHS/United States HHSN261201500003I/CA/NCI NIH HHS/United States P01 AI131338/AI/NIAID NIH HHS/United States UM1 AI164562/AI/NIAID NIH HHS/United States

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