CRISPR-Cas12a-integrated transgenes in genomic safe harbors retain high expression in human hematopoietic iPSC-derived lineages and primary cells.

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第一作者： Arsenios,Vlassis

第一单位： Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.

作者： Arsenios,Vlassis ^[1] ; Tanja L,Jensen ^[1] ; Marina,Mohr ^[1] ; Dominika J,Jedrzejczyk ^[1] ; Xiangyou,Meng ^[1] ; Gergo,Kovacs ^[2] ; Martí,Morera-Gómez ^[1] ; Andrea,Barghetti ^[3] ; Sergi,Muyo Abad ^[1] ; Roland F,Baumgartner ^[3] ; Kedar N,Natarajan ^[2] ; Lars K,Nielsen ^[4] ; Tanya,Warnecke ^[3] ; Ryan T,Gill ^[3]

作者单位： Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark. ^[1] DTU Bioengineering, Technical University of Denmark, Søltofts Plads 224, 2800 Kongens Lyngby, Denmark. ^[2] Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.;Artisan Bio, 363 Centennial Parkway, Suite 310, Louisville, CO 80027, USA. ^[3] Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet 220, 2800 Kongens Lyngby, Denmark.;Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD 4072, Australia. ^[4]

关键词 Cell biology Molecular Genetics Molecular biology Stem cells research Techniques in genetics

DOI 10.1016/j.isci.2023.108287

PMID 38034357

发布时间 2023-12-02

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CRISPR-Cas12a-integrated transgenes in genomic safe harbors retain high expression in human hematopoietic iPSC-derived lineages and primary cells.

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CRISPR-Cas12a-integrated transgenes in genomic safe harbors retain high expression in human hematopoietic iPSC-derived lineages and primary cells.

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