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Design and synthesis of the first PARP-1 and proteasome dual inhibitors to treat breast cancer.

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第一作者： Hualong,He

第一单位： Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.

作者： Hualong,He ^[1] ; Wan,Yang ^[1] ; Yaojie,Shi ^[1] ; Xin,Chen ^[2] ; Xinyi,Chen ^[1] ; Xiang,Hu ^[1] ; Xinyue,Li ^[1] ; Yingyue,Yang ^[2] ; Zhihao,Liu ^[1] ; Tinghong,Ye ^[1] ; Ningyu,Wang ^[3] ; Luoting,Yu ^[4]

作者单位： Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. ^[1] School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. ^[2] School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. Electronic address: wangny-swjtu@swjtu.edu.cn. ^[3] Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: yuluot@scu.edu.cn. ^[4]

关键词 Cancer therapy DNA damage Dual inhibitors PARP-1 Proteasome

医学主题词人类(Humans);女(雌)性(Female);乳腺肿瘤(Breast Neoplasms);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);细胞系, 肿瘤(Cell Line, Tumor);DNA(DNA);酞嗪类(Phthalazines)

DOI 10.1016/j.ejmech.2023.115943

PMID 38039793

发布时间 2024-01-06

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