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Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.

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第一作者: David E,Harrison
第一单位: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA. david.harrison@jax.org.
作者单位: The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA. david.harrison@jax.org. [1] Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.;Education, and Clinical Center, Geriatric Research, San Antonio, TX, USA.;Research Service, South Texas Veterans Health Care System, San Antonio, TX, USA.;Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA. [2] The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA. [3] Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.;Education, and Clinical Center, Geriatric Research, San Antonio, TX, USA.;Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA. [4] Department of Psychiatry, The University of Texas Health Science Center, San Antonio, TX, USA. [5] Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.;Department of Physiology, The University of Texas Health Sciences Center, San Antonio, TX, USA. [6] John A. Burns School of Medicine, University of Hawai'I at Mānoa, Honolulu, HI, USA. [7] , Cardax, Honolulu, HI, USA.;AX3 Life, Honolulu, HI, USA. [8] Department of Molecular Biosciences, University of California, Davis, CA, USA. [9] Mayo Clinic, Rochester, MN, USA. [10] University of Minnesota, Minneapolis, MN, USA. [11] Harvard School of Public Health, Boston, MA, USA. [12] Department of Basic Medical Sciences, School of Medicine, Koç University, 34450, Istanbul, Turkey. [13] Department of Internal Medicine, Yale University, New Haven, CT, USA. [14] Department of Molecular Medicine, The University of Texas Health Sciences Center, San Antonio, TX, USA. [15] Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.;Education, and Clinical Center, Geriatric Research, San Antonio, TX, USA.;Research Service, South Texas Veterans Health Care System, San Antonio, TX, USA.;Department of Molecular Medicine, The University of Texas Health Sciences Center, San Antonio, TX, USA. [16] Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA. [17] Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA. [18]
DOI 10.1007/s11357-023-01011-0
PMID 38041783
发布时间 2025-02-26
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