Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.

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第一作者： Liora S,Katz

第一单位： Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1152, New York, NY 10029, USA.

作者： Liora S,Katz ^[1] ; Gabriel,Brill ^[2] ; Peng,Wang ^[1] ; Luca,Lambertini ^[1] ; Pili,Zhang ^[1] ; Jonathan M,Haldeman ^[3] ; Hongtao,Liu ^[1] ; Christopher B,Newgard ^[3] ; Andrew F,Stewart ^[1] ; Adolfo,Garcia-Ocaña ^[4] ; Donald K,Scott ^[5]

作者单位： Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1152, New York, NY 10029, USA. ^[1] Pharmacologic Sciences Department, Stony Brook University, Stony Brook, NY, USA(5). ^[2] Stedman Center, Duke University School of Medicine, USA. ^[3] Arthur Riggs Diabetes & Metabolism Research Institute, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA. ^[4] Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1152, New York, NY 10029, USA. Electronic address: donald.scott@mssm.edu. ^[5]

关键词 Beta cells ChREBP Chromatin conformation capture DNA looping Glucose-mediated gene expression Glucose-stimulated beta cell proliferation Myc Pvt1

主题词动物(Animals);大鼠(Rats);染色质(Chromatin);DNA(DNA);基因, myc(Genes, myc);葡萄糖(Glucose);转录因子(Transcription Factors);转录激活(Transcriptional Activation);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc)

DOI 10.1016/j.molmet.2023.101848

PMID 38042369

发布时间 2024-02-01

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Molecular metabolism

2024年79卷

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Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.

Molecular metabolism

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Molecular metabolism

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Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.

Molecular metabolism

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Molecular metabolism

相关期刊

检索历史清除