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Clinical implications of incorporating genetic and non-genetic risk factors in CanRisk-based breast cancer risk prediction.

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第一作者： Anja,Tüchler

第一单位： Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany.

作者： Anja,Tüchler ^[1] ; Antoine,De Pauw ^[2] ; Corinna,Ernst ^[1] ; Amélie,Anota ^[3] ; Inge M M,Lakeman ^[4] ; Julia,Dick ^[1] ; Nienke,van der Stoep ^[5] ; Christi J,van Asperen ^[5] ; Monika,Maringa ^[1] ; Natalie,Herold ^[1] ; Britta,Blümcke ^[1] ; Robert,Remy ^[1] ; Anke,Westerhoff ^[1] ; Denise J,Stommel-Jenner ^[6] ; Eléonore,Frouin ^[7] ; Lisa,Richters ^[1] ; Lisa,Golmard ^[2] ; Nadine,Kütting ^[1] ; Chrystelle,Colas ^[8] ; Barbara,Wappenschmidt ^[1] ; Kerstin,Rhiem ^[1] ; Peter,Devilee ^[9] ; Dominique,Stoppa-Lyonnet ^[10] ; Rita K,Schmutzler ^[1] ; Eric,Hahnen ^[11]

作者单位： Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany. ^[1] Institut Curie, Department of Genetics, Paris, France; Université PSL, Paris, France. ^[2] Department of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France; Human and Social Sciences Department, Centre Léon Bérard, Lyon, France; French National Platform Quality of Life and Cancer, Centre Léon Bérard, Lyon, France. ^[3] Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. ^[4] Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. ^[5] Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. ^[6] Université PSL, Paris, France; Clinical Bioinformatics Unit, Institut Curie, Paris, France. ^[7] Institut Curie, Department of Genetics, Paris, France; Université PSL, Paris, France; Institut Curie, Inserm U830, Paris, France. ^[8] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. ^[9] Institut Curie, Department of Genetics, Paris, France; Institut Curie, Inserm U830, Paris, France; Université Paris Cité, Paris, France. ^[10] Center for Familial Breast and Ovarian and Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital of Cologne, Cologne, Germany. Electronic address: eric.hahnen@uk-koeln.de. ^[11]

关键词 Breast cancer Cancer prevention Genetic testing Hereditary breast and ovarian cancer syndrome