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ERK hyperactivation serves as a unified mechanism of escape in intrinsic and acquired CDK4/6 inhibitor resistance in acral lentiginous melanoma.

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第一作者： Kasturee,Jagirdar

第一单位： Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

作者： Kasturee,Jagirdar ^[1] ; Marie E,Portuallo ^[1] ; Meihan,Wei ^[1] ; Matthew,Wilhide ^[1] ; Jeremy A,Bravo Narula ^[1] ; Bailey M,Robertson ^[1] ; Gretchen M,Alicea ^[2] ; Crystal,Aguh ^[3] ; Min,Xiao ^[4] ; Tetiana,Godok ^[4] ; Dylan,Fingerman ^[4] ; Gregory Schuyler,Brown ^[4] ; Meenhard,Herlyn ^[4] ; Vissy M,Elad ^[1] ; Xinyu,Guo ^[5] ; Eneda,Toska ^[5] ; Daniel J,Zabransky ^[5] ; Bradley,Wubbenhorst ^[6] ; Katherine L,Nathanson ^[6] ; Shawn,Kwatra ^[3] ; Yogesh,Goyal ^[7] ; Hongkai,Ji ^[8] ; Qin,Liu ^[4] ; Vito W,Rebecca ^[9]

作者单位： Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ^[1] Department of Chemical and Biomolecular Engineering, The Johns Hopkins Whiting School of Engineering, Baltimore, MD, USA. ^[2] Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, USA. ^[3] The Wistar Institute, Molecular and Cellular Oncogenesis Program and Melanoma Research Center, Philadelphia, PA, USA. ^[4] Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. ^[5] Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. ^[6] Department of Cell and Developmental Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. ^[7] Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ^[8] Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. vrebecc2@jh.edu.;Sidney Kimmel Comprehensive Cancer Center and Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA. vrebecc2@jh.edu. ^[9]