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Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study.

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作者单位: Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Perelman Center for Advanced Medicine, SPE 8-112, Philadelphia, PA, 19104, USA. [1] Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. [2] Biopharmaceutical Research Center, AbClon Inc., #1401, Ace Twin Tower1, 285 Digital-Ro, Guro-Gu, Seoul, Korea. [3] Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, Korea. [4] Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. [5] Ajou University Hospital, Suwon, Korea. [6] Division of Hematology-Oncology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. [7] College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Korea. [8] Department of Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA. [9] Biopharmaceutical Research Center, AbClon Inc., #1401, Ace Twin Tower1, 285 Digital-Ro, Guro-Gu, Seoul, Korea. jslee@abclon.com. [10] Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, Korea. dhyoon@amc.seoul.kr. [11] Cancer Research Institute, Seoul National University College of Medicine, Suite 510, Samsung Cancer Research Building, 103 Daehak-Ro, Jongno-Gu, Seoul, Korea. jjhchung@snu.ac.kr. [12] Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Perelman Center for Advanced Medicine, SPE 8-112, Philadelphia, PA, 19104, USA. mruella@upenn.edu. [13] Division of Hematology-Oncology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu. [14] Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. mruella@upenn.edu. [15]
DOI 10.1186/s12943-023-01886-9
PMID 38066564
发布时间 2024-06-15
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