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Exploring the In Vitro and In Vivo Therapeutic Potential of BRAF and MEK Inhibitor Combination in NRAS-Mutated Melanoma.

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第一作者： Heike,Niessner

第一单位： Division of Dermatooncology, Department of Dermatology, University of Tuebingen, Liebermeisterstr. 25, 72076 Tuebingen, Germany.;Cluster of Excellence iFIT (EXC 2180) "Image Guided and Functionally Instructed Tumor Therapies", 72076 Tuebingen, Germany.

作者： Heike,Niessner ^[1] ; Anna,Hüsch ^[2] ; Corinna,Kosnopfel ^[3] ; Matthias,Meinhardt ^[4] ; Dana,Westphal ^[5] ; Friedegund,Meier ^[6] ; Bastian,Schilling ^[7] ; Tobias,Sinnberg ^[8]

作者单位： Division of Dermatooncology, Department of Dermatology, University of Tuebingen, Liebermeisterstr. 25, 72076 Tuebingen, Germany.;Cluster of Excellence iFIT (EXC 2180) "Image Guided and Functionally Instructed Tumor Therapies", 72076 Tuebingen, Germany. ^[1] Division of Dermatooncology, Department of Dermatology, University of Tuebingen, Liebermeisterstr. 25, 72076 Tuebingen, Germany. ^[2] Department of Hematology, Oncology and Pneumology, University Hospital Muenster, 48149 Muenster, Germany. ^[3] Department of Pathology, Medical Faculty and University Hospital Carl Gustav Carus, TU Dresden, 01307 Dresden, Germany.;National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany. ^[4] National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.;Department of Dermatology, Carl Gustav Carus Medical Center, TU Dresden, 01307 Dresden, Germany. ^[5] National Center for Tumor Diseases (NCT), Partner Site Dresden, 01307 Dresden, Germany.;Department of Dermatology, Carl Gustav Carus Medical Center, TU Dresden, 01307 Dresden, Germany.;Center for Regenerative Therapies Dresden, TU Dresden, 01307 Dresden, Germany. ^[6] Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. ^[7] Division of Dermatooncology, Department of Dermatology, University of Tuebingen, Liebermeisterstr. 25, 72076 Tuebingen, Germany.;Cluster of Excellence iFIT (EXC 2180) "Image Guided and Functionally Instructed Tumor Therapies", 72076 Tuebingen, Germany.;Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. ^[8]

关键词 BRAF inhibitor NRAS-mutated PDX (patient-derived xenograft) mouse model binimetinib cancer encorafenib malignant melanoma

DOI 10.3390/cancers15235521

PMID 38067230

发布时间 2024-10-15

基金项目

N/A/Pierre Fabre

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