Pharmacological Inhibition of PIP4K2 Potentiates Venetoclax-Induced Apoptosis in Acute Myeloid Leukemia.

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第一作者： Keli,Lima

第一单位： Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo CEP 13566-590, Brazil.

作者： Keli,Lima ^[1] ; Maria Fernanda Lopes,Carvalho ^[2] ; Diego Antonio,Pereira-Martins ^[2] ; Frederico Lisboa,Nogueira ^[1] ; Lívia Bassani Lins,de Miranda ^[3] ; Mariane Cristina do,Nascimento ^[1] ; Rita de Cássia,Cavaglieri ^[2] ; Jan Jacob,Schuringa ^[1] ; João Agostinho,Machado-Neto ^[2] ; Eduardo Magalhães,Rego ^[2]

作者单位： Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo CEP 13566-590, Brazil. ^[1] Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo CEP 13566-590, Brazil. ^[2] Department of Experimental Hematology, University of Groningen, 9718 BG Groningen, The Netherlands. ^[3]

关键词 THZ-P1-2 acute myeloid leukemia phosphatidylinositol-5-phosphate 4-kinase type 2 venetoclax

主题词人类(Humans);细胞系, 肿瘤(Cell Line, Tumor);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);细胞凋亡(Apoptosis);抗肿瘤药(Antineoplastic Agents);磷酸转移酶类(醇族体)(Phosphotransferases (Alcohol Group Acceptor))

DOI 10.3390/ijms242316899

PMID 38069220

发布时间 2023-12-16

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