Modular and tunable alternative surfactants for biopharmaceuticals provide insights into Surfactant's Structure-Function relationship.

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作者： Stefano,Cucuzza ^[1] ; Sebastian,Brosig ^[1] ; Tim,Serno ^[1] ; Karoline,Bechtold-Peters ^[1] ; Jure,Cerar ^[2] ; Michael,Kammüller ^[3] ; Fabrice,Gallou ^[4]

作者单位： Novartis Pharma AG, TRD Biologics & CGT, GDD, 4002 Basel, Switzerland. ^[1] Novartis Pharma AG, TRD Biologics & CGT, GDD, 1234 Menges, Slovenia. ^[2] Novartis Pharma AG, NIBR, CH-4002 Basel, Switzerland. ^[3] Novartis Pharma AG, CHAD, CH-4002 Basel, Switzerland. ^[4]

关键词 Drug Development In vitro safety Polysorbates Protein-surfactant Interactions Surface Tension Surfactants

主题词表面活性剂(Surface-Active Agents);聚山梨醇酯类(Polysorbates);生物制品(Biological Products);泊洛沙姆(Poloxamer);肺表面活性剂(Pulmonary Surfactants);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ijpharm.2023.123692

PMID 38081561

发布时间 2024-01-08

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