Mitochondrial targeting derivatives of honokiol enhanced selective antitumor activity in NCI-H446 cells and decreased in vivo toxicity in Caenorhabditis elegans.

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作者： Huicong,Miao ^[1] ; Wenbo,Cui ^[1] ; Tao,Zhang ^[2] ; Yue,Zhang ^[1] ; Jiaozhen,Zhang ^[1] ; Hongxiang,Lou ^[3] ; Peihong,Fan ^[4]

作者单位： Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. ^[1] Shandong Provincial Key Laboratory of Neuroprotective Drugs, Shandong Qidu Pharmaceutical Research Institute, Zibo 255400, PR China. ^[2] Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. Electronic address: louhongxiang@sdu.edu.cn. ^[3] Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, PR China. Electronic address: fanpeihong@sdu.edu.cn. ^[4]

关键词 Antitumor DLCs F16 Honokiol Mitochondria targeting

主题词动物(Animals);秀丽新小杆线虫(Caenorhabditis elegans);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);木酚素类(Lignans);联苯化合物(Biphenyl Compounds);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1016/j.ejmech.2023.115996

PMID 38086195

发布时间 2024-01-01

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European journal of medicinal chemistry

2024年264卷

115996页

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Mitochondrial targeting derivatives of honokiol enhanced selective antitumor activity in NCI-H446 cells and decreased in vivo toxicity in Caenorhabditis elegans.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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Mitochondrial targeting derivatives of honokiol enhanced selective antitumor activity in NCI-H446 cells and decreased in vivo toxicity in Caenorhabditis elegans.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

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