Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.

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作者： Riccardo,Guidi ^[1] ; Christopher,Wedeles ^[1] ; Daqi,Xu ^[1] ; Krzysztof,Kolmus ^[2] ; Sarah E,Headland ^[1] ; Grace,Teng ^[1] ; Joseph,Guillory ^[3] ; Yi Jimmy,Zeng ^[4] ; Tommy K,Cheung ^[4] ; Subhra,Chaudhuri ^[3] ; Zora,Modrusan ^[3] ; Yuxin,Liang ^[3] ; Stuart,Horswell ^[5] ; Benjamin,Haley ^[6] ; Sascha,Rutz ^[7] ; Christopher,Rose ^[4] ; Yvonne,Franke ^[8] ; Donald S,Kirkpatrick ^[4] ; Jason A,Hackney ^[2] ; Mark S,Wilson ^[9]

作者单位： Immunology Discovery, Genentech, South San Francisco, CA 94080, USA. ^[1] OMNI Bioinformatics, Genentech, South San Francisco, CA 94080, USA. ^[2] Next Generation Sequencing (NGS), Genentech, South San Francisco, CA 94080, USA. ^[3] Microchemistry, Proteomics and Lipidomics, Genentech, South San Francisco, CA 94080, USA. ^[4] Bioinformatic and Biostatistics, The Francis Crick Institute, London, UK. ^[5] Molecular Biology, Genentech, South San Francisco, CA 94080, USA. ^[6] Cancer Immunology, Genentech, South San Francisco, CA 94080, USA. ^[7] Protein Sciences, Genentech, South San Francisco, CA 94080, USA. ^[8] Immunology Discovery, Genentech, South San Francisco, CA 94080, USA. Electronic address: wilson.mark@gene.com. ^[9]

关键词 CP: Immunology CP: Molecular biology IL-13 RNAi T cell T(H)2 allergy eosinophil gene regulation helminth lymphocyte miRNA