Development of membrane-targeting TPP<sup>+</sup>-chloramphenicol conjugates to combat methicillin-resistant staphylococcus aureus (MRSA) infections.

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作者： Tao,Li ^[1] ; Xiaoli,He ^[2] ; Wenlan,Tao ^[2] ; Ruixue,Zhang ^[1] ; Qiaolin,He ^[1] ; Hongzhi,Gong ^[1] ; Ye,Liu ^[1] ; Dong,Luo ^[1] ; Maojie,Zhang ^[1] ; Cheng,Zou ^[1] ; Shao-Lin,Zhang ^[3] ; Yun,He ^[4]

作者单位： School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China. ^[1] Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, 266 Fangzheng Ave, Shuitu Technology Development Zone, Beibei, Chongqing, 400714, PR China. ^[2] School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China; State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, 518055, PR China. Electronic address: zhangsl@cqu.edu.cn. ^[3] School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, No. 55 Daxuecheng South Rd., Shapingba, Chongqing, 401331, PR China; Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, 266 Fangzheng Ave, Shuitu Technology Development Zone, Beibei, Chongqing, 400714, PR China. Electronic address: yun.he@cqu.edu.cn. ^[4]

关键词 Drug-resistance Membrane disruption Triphenylphosphonium cation

主题词动物(Animals);小鼠(Mice);氯霉素(Chloramphenicol);耐甲氧西林金黄色葡萄球菌(Methicillin-Resistant Staphylococcus aureus);微生物敏感性试验(Microbial Sensitivity Tests);抗菌药(Anti-Bacterial Agents);葡萄球菌感染(Staphylococcal Infections)

DOI 10.1016/j.ejmech.2023.115973

PMID 38096652

发布时间 2024-01-02

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