Safety and antitumor activity of metformin plus lanreotide in patients with advanced gastro-intestinal or lung neuroendocrine tumors: the phase Ib trial MetNET2.

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作者： Sara,Pusceddu ^[1] ; Francesca,Corti ^[2] ; Natalie,Prinzi ^[3] ; Federico,Nichetti ^[2] ; Silva,Ljevar ^[2] ; Adele,Busico ^[4] ; Tommaso,Cascella ^[5] ; Rita,Leporati ^[6] ; Simone,Oldani ^[2] ; Chiara Carlotta,Pircher ^[2] ; Jorgelina,Coppa ^[2] ; Veronica,Resi ^[7] ; Massimo,Milione ^[8] ; Marco,Maccauro ^[9] ; Rosalba,Miceli ^[10] ; Elena,Tamborini ^[4] ; Federica,Perrone ^[5] ; Carlo,Spreafico ^[5] ; Monica,Niger ^[6] ; Federica,Morano ^[2] ; Filippo,Pietrantonio ^[2] ; Ettore,Seregni ^[2] ; Luigi,Mariani ^[10] ; Vincenzo,Mazzaferro ^[4] ; Giorgia,Di Liberti ^[7] ; Giovanni,Fucà ^[11] ; Filippo,de Braud ^[2] ; Claudio,Vernieri ^[2]

作者单位： Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Via Venezian 1, 20133, Milan, Italy. sara.pusceddu@istitutotumori.mi.it. ^[1] Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Via Venezian 1, 20133, Milan, Italy. ^[2] SC Medical Oncology, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy. ^[3] Clinical Epidemiology and Trial Organization, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori Di Milano, Milan, Italy. ^[4] Department of Advanced Diagnostics, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy. ^[5] Department of Radiology Foundation IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy. ^[6] Hepato-Biliary-Pancreatic and Upper G.I. Surgery, Liver Transplantation and Hepato-Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy. ^[7] Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. ^[8] Department of the Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy. ^[9] Departement of Nuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Milan, Italy. ^[10] Department of Oncology and Hemato-Oncology, Università deli Studi di Milano, Milan, Italy. ^[11] Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, ENETS Center of Excellence, Via Venezian 1, 20133, Milan, Italy. claudio.vernieri@istitutotumori.mi.it. ^[12] IFOM ETS - The AIRC Institute of Molecular Oncology, Via Ademello 16, 20139, Milan, Italy. claudio.vernieri@istitutotumori.mi.it. ^[13]

关键词 Antitumor activity Metformin plus lanreotide Phase Ib trial Safety Well-differentiated neuroendocrine tumors (WDNETs)