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5'-Methylthioadenosine strongly suppresses RANKL-induced osteoclast differentiation and function via inhibition of RANK-NFATc1 signalling pathways.

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第一作者： Purithat,Rattajak

第一单位： Division of Health and Applied Science (Biochemistry), Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, 90110, Thailand.

作者： Purithat,Rattajak ^[1] ; Aratee,Aroonkesorn ^[2] ; Carl,Smythe ^[3] ; Rapepun,Wititsuwannakul ^[4] ; Thanawat,Pitakpornpreecha ^[2]

作者单位： Division of Health and Applied Science (Biochemistry), Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, 90110, Thailand. ^[1] Division of Health and Applied Science (Biochemistry), Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla, 90110, Thailand.;Center for Natural Rubber Latex Biotechnology Research and Innovation Development, Prince of Songkla University, Hat-Yai, Songkhla, 90110, Thailand. ^[2] Department of Biomedical Science, University of Sheffield, Sheffield, England S10 2TN, UK. ^[3] Center for Natural Rubber Latex Biotechnology Research and Innovation Development, Prince of Songkla University, Hat-Yai, Songkhla, 90110, Thailand. ^[4]

关键词 5′-methylthioadenosine (MTA)Bone mass Estrogen Osteoclastogenesis Osteoporosis RAW 264.7?cells

DOI 10.1016/j.heliyon.2023.e22365

PMID 38099006

发布时间 2023-12-16

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5'-Methylthioadenosine strongly suppresses RANKL-induced osteoclast differentiation and function via inhibition of RANK-NFATc1 signalling pathways.

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5'-Methylthioadenosine strongly suppresses RANKL-induced osteoclast differentiation and function via inhibition of RANK-NFATc1 signalling pathways.

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