NDUFA12 as a Functional Target of the Anticancer Compound Ertredin in Human Hepatoma Cells As Revealed by Label-Free Chemical Proteomics.

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作者： Se In,Park ^[1] ; Sung Min,Cho ^[1] ; Sonoko,Atsumi ^[2] ; Manabu,Kawada ^[2] ; Masabumi,Shibuya ^[3] ; Ju Yeon,Lee ^[4] ; Jin Young,Kim ^[5] ; Ho Jeong,Kwon ^[4]

作者单位： Chemical Genomics Leader Research Laboratory, Department of Biotechnology College of Life Science & Biotechnology, Yonsei University, Seoul 03722, Korea. ^[1] Laboratory of Oncology, Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku 141-0021, Tokyo, Japan. ^[2] Institute of Physiology and Medicine, Jobu University, Takasaki-shi, Gunma 370-1393, Japan. ^[3] Research Center of Bioconvergence Analysis, Korea Basic Science Institute, Ochang 28119, Korea. ^[4] Critical Diseases Diagnostics Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea. ^[5]

关键词 CETSA DARTS Ertredin LC?MS/MS NDUFA12 anticancer agent mitochondria complex 1 target identification

主题词人类(Humans);癌, 肝细胞(Carcinoma, Hepatocellular);蛋白质组学(Proteomics);蛋白质类(Proteins);肝肿瘤(Liver Neoplasms);NADPH脱氢酶(NADPH Dehydrogenase)

DOI 10.1021/acs.jproteome.3c00471

PMID 38104258

发布时间 2024-03-13

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