Naringin alleviates pneumonia caused by Klebsiella pneumoniae infection by suppressing NLRP3 inflammasome.

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作者： Xiao-Han,Jing ^[1] ; Guan-Yu,Zhao ^[2] ; Gui-Bo,Wang ^[1] ; Qi-Lin,Huang ^[1] ; Wen-Shu,Zou ^[1] ; Li-Na,Huang ^[3] ; Wei,Li ^[4] ; Zheng-Ying,Qiu ^[5] ; Rui-Hua,Xin ^[6]

作者单位： Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences (CAAS), China; Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs of P.R. China, China. ^[1] College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China. ^[2] School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, China. ^[3] Lanzhou Center for Disease Control and Prevention, Lanzhou, China. Electronic address: 349665516@qq.com. ^[4] Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences (CAAS), China; Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs of P.R. China, China. Electronic address: qiumoying@163.com. ^[5] Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences (CAAS), China; Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, China; Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs of P.R. China, China. Electronic address: xinruihua@caas.cn. ^[6]

关键词 Anti-inflammatory mechanism Klebsiella pneumoniae NLRP3 inflammasome Naringin Protein assembly

主题词小鼠(Mice);动物(Animals);炎性体(Inflammasomes);肺炎克雷伯菌(Klebsiella pneumoniae);NF-κB(NF-kappa B);肺炎(Pneumonia)

DOI 10.1016/j.biopha.2023.116028

PMID 38113627

发布时间 2024-01-10

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