Vascular organs-on-chip made with patient-derived endothelial cells: technologies to transform drug discovery and disease modeling.

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第一作者： Chloe P,Whitworth

第一单位： Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

作者： Chloe P,Whitworth ^[1] ; William J,Polacheck ^[2]

作者单位： Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[1] Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[2] Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. ^[3] McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ^[4] Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, USA. ^[5]

关键词 Blood outgrowth endothelial cell Vascular disease disease modeling drug discovery endothelial colony forming cell induced pluripotent stem cells organ-on-chip

主题词动物(Animals);人类(Humans);内皮细胞(Endothelial Cells);药物发现(Drug Discovery);诱导多能干细胞(Induced Pluripotent Stem Cells);药物评价, 临床前(Drug Evaluation, Preclinical);芯片实验室装置(Lab-On-A-Chip Devices)

DOI 10.1080/17460441.2023.2294947

PMID 38117223

发布时间 2024-03-09

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