Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study.

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第一作者： Alix,Miauton

第一单位： Tropical, Travel and Vaccination Clinic, Centre for Primary Care and Public Health (Unisanté), Lausanne, Switzerland. Electronic address: alix.miauton@unisante.ch.

作者： Alix,Miauton ^[1] ; Régine,Audran ^[2] ; Juliette,Besson ^[3] ; Hélène,Maby-El Hajjami ^[4] ; Maxime,Karlen ^[3] ; Loane,Warpelin-Decrausaz ^[5] ; Loredana,Sene ^[4] ; Sylvain,Schaufelberger ^[6] ; Vincent,Faivre ^[6] ; Mohamed,Faouzi ^[7] ; Mary-Anne,Hartley ^[3] ; François,Spertini ^[2] ; Blaise,Genton ^[3]

作者单位： Tropical, Travel and Vaccination Clinic, Centre for Primary Care and Public Health (Unisanté), Lausanne, Switzerland. Electronic address: alix.miauton@unisante.ch. ^[1] Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. ^[2] Tropical, Travel and Vaccination Clinic, Centre for Primary Care and Public Health (Unisanté), Lausanne, Switzerland. ^[3] Clinical Trial Unit, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland. ^[4] Clinical Trial Unit, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland; Research Support Unit, Centre for Primary Care and Public Health (Unisanté), Lausanne, Switzerland. ^[5] Information Systems and Digital Transformation, Centre for Primary Care and Public Health (Unisanté), Lausanne, Switzerland. ^[6] Biostatistics Unit, Centre for Primary Care and Public Health (Unisanté), Lausanne, Switzerland. ^[7]

关键词 Dengue vaccine Dengue virus Nanoparticle-based vaccine T cell immunity

主题词成年人(Adult);人类(Humans);瑞士(Switzerland);金(Gold);金属纳米粒子(Metal Nanoparticles);疫苗, 合成(Vaccines, Synthetic);抗体, 病毒(Antibodies, Viral);双盲法(Double-Blind Method);登革热(Dengue);肽类(Peptides)

DOI 10.1016/j.ebiom.2023.104922

PMID 38128414

发布时间 2024-01-22

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Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study.

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Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 study.

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