Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants.

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作者： Zhongfeng,Ye ^[1] ; Srinivasa Reddy,Bonam ^[2] ; Lindsay G A,McKay ^[3] ; Jessica A,Plante ^[2] ; Jordyn,Walker ^[4] ; Yu,Zhao ^[2] ; Changfeng,Huang ^[4] ; Jinjin,Chen ^[1] ; Chutian,Xu ^[1] ; Yamin,Li ^[1] ; Lihan,Liu ^[1] ; Joseph,Harmon ^[5] ; Shuliang,Gao ^[1] ; Donghui,Song ^[1] ; Zhibo,Zhang ^[1] ; Kenneth S,Plante ^[1] ; Anthony,Griffiths ^[1] ; Jianzhu,Chen ^[2] ; Haitao,Hu ^[4] ; Qiaobing,Xu ^[3]

作者单位： Department of Biomedical Engineering, Tufts University, Medford, MA 02155. ^[1] Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555. ^[2] National Emerging Infectious Diseases Laboratories and Department of Virology, Immunology, and Microbiology, Chobanian & Avedisian School of Medicine, Boston University, Boston, MA 02215. ^[3] World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX 77555. ^[4] Department of Pharmacology, State University of New York Upstate Medical University, Syracuse, NY 13210. ^[5] Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139. ^[6]

关键词 lipid nanoparticle lung tissue-resident memory T cells mRNA vaccine untranslated region