Dual target PARP1/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy.

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第一作者： Xinxin,Li

第一单位： Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.

作者： Xinxin,Li ^[1] ; Cheng,Wang ^[1] ; Shang,Li ^[1] ; Fucheng,Yin ^[1] ; Heng,Luo ^[1] ; Yonglei,Zhang ^[1] ; Zhongwen,Luo ^[1] ; Yifan,Chen ^[1] ; Siyuan,Wan ^[1] ; Lingyi,Kong ^[2] ; Xiaobing,Wang ^[3]

作者单位： Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. ^[1] Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: cpu_lykong@126.com. ^[2] Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. Electronic address: xbwang@cpu.edu.cn. ^[3]

关键词 EZH2 PARP Synthetic lethality Triple-negative breast cancer

主题词人类(Humans);细胞系, 肿瘤(Cell Line, Tumor);自噬(Autophagy)

DOI 10.1016/j.ejmech.2023.116054

PMID 38134746

发布时间 2024-01-17

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准确一般字义偏差语意偏离译文作用小提交