Structural Insights into the Activation of Human Aryl Hydrocarbon Receptor by the Environmental Contaminant Benzo[a]pyrene and Structurally Related Compounds.

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作者： Hok-Sau,Kwong ^[1] ; Matteo,Paloni ^[1] ; Loïc,Grandvuillemin ^[1] ; Savannah,Sirounian ^[1] ; Aurélie,Ancelin ^[1] ; Josephine,Lai-Kee-Him ^[1] ; Marina,Grimaldi ^[2] ; Coralie,Carivenc ^[1] ; Claudia,Lancey ^[3] ; Timothy J,Ragan ^[3] ; Emma L,Hesketh ^[3] ; Patrick,Balaguer ^[2] ; Alessandro,Barducci ^[1] ; Jakub,Gruszczyk ^[4] ; William,Bourguet ^[5]

作者单位： CBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, Inserm, Montpellier, France. ^[1] IRCM (Institut de Recherche en Cancérologie de Montpellier), Univ Montpellier, Inserm, ICM, Montpellier, France. ^[2] Leicester Institute of Structural & Chemical Biology and Department of Molecular & Cell Biology, University of Leicester, Lancaster Rd, Leicester LE1 7HB, UK. ^[3] CBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, Inserm, Montpellier, France. Electronic address: jakub.gruszczyk@cbs.cnrs.fr. ^[4] CBS (Centre de Biologie Structurale), Univ Montpellier, CNRS, Inserm, Montpellier, France. Electronic address: william.bourguet@cbs.cnrs.fr. ^[5]

关键词 AHR B[a]P PAH Polycyclic aromatic hydrocarbon cryo-EM

主题词人类(Humans);苯并芘(Benzo(a)pyrene);结合部位(Binding Sites);配体(Ligands);受体, 芳基烃(Receptors, Aryl Hydrocarbon);环境污染物(Environmental Pollutants)

DOI 10.1016/j.jmb.2023.168411

PMID 38135181

发布时间 2024-11-27

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