Increased IGFBP Proteolysis, IGF-I Bioavailability, and Pappalysin Levels in Children With Prader-Willi Syndrome.

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作者： Vicente,Barrios ^[1] ; Álvaro,Martín-Rivada ^[2] ; Gabriel Á,Martos-Moreno ^[3] ; Sandra,Canelles ^[1] ; Francisca,Moreno-Macián ^[4] ; Carmen,De Mingo-Alemany ^[4] ; Maurizio,Delvecchio ^[5] ; Roberta,Pajno ^[6] ; Danilo,Fintini ^[7] ; Julie A,Chowen ^[8] ; Jesús,Argente ^[9]

作者单位： Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute "La Princesa", Madrid 28009, Spain.;Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN), Instituto de Salud Carlos III, Madrid 28029, Spain. ^[1] Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute "La Princesa", Madrid 28009, Spain. ^[2] Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute "La Princesa", Madrid 28009, Spain.;Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN), Instituto de Salud Carlos III, Madrid 28029, Spain.;Department of Pediatrics, Universidad Autónoma de Madrid, Madrid 28029, Spain. ^[3] Pediatric Endocrinology Unit, Hospital Universitario y Politécnico La Fe, Valencia 46009, Spain. ^[4] Department of Biotechnology and Applied Sciences, University of L'Aquila, Aquila 67100, Italy. ^[5] Department of Pediatrics, Endocrine Unit, IRCCS San Raffaele Scientific Institute, Milan 20132, Italy. ^[6] Ospedale Pediatrico Bambino Gesù, Prader-Willi Reference Center, Endocrinology and Diabetology Unit, IRCCS, Rome 00165, Italy. ^[7] Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute "La Princesa", Madrid 28009, Spain.;Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN), Instituto de Salud Carlos III, Madrid 28029, Spain.;IMDEA, Food Institute, CEIUAM+CSI, Cantoblanco, Madrid 28049, Spain. ^[8] Departments of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Niño Jesús, Research Institute "La Princesa", Madrid 28009, Spain.;Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutriciόn (CIBEROBN), Instituto de Salud Carlos III, Madrid 28029, Spain.;Department of Pediatrics, Universidad Autónoma de Madrid, Madrid 28029, Spain.;IMDEA, Food Institute, CEIUAM+CSI, Cantoblanco, Madrid 28049, Spain. ^[9]

关键词 GH treatment IGFBP PAPP-A Prader-Willi syndrome STC-1 free IGF-I