Synthesis and biological evaluation of 2'-hydroxychalcone derivatives as AMPK activators.

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作者： Duy,Vu Nguyen ^[1] ; Chatchai,Muanprasat ^[2] ; Suchada,Kaewin ^[3] ; Kowit,Hengphasatporn ^[4] ; Yasuteru,Shigeta ^[4] ; Thanyada,Rungrotmongkol ^[5] ; Warinthorn,Chavasiri ^[6]

作者单位： Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand. ^[1] Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn 10540, Thailand. ^[2] Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bang Phli, Samut Prakarn 10540, Thailand; Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok, 10400, Thailand. ^[3] Center for Computational Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan. ^[4] Bioinformatics and Computational Biology Program, Graduated School, Chulalongkorn University, Bangkok 10330, Thailand; Center of Excellence in Biocatalyst and Sustainable Biotechnology, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. ^[5] Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand. Electronic address: warinthorn.c@chula.ac.th. ^[6]

关键词 2′-Hydroxychalcone AMPK activation CaMKKβ Molecular docking study Podocytes Structure-activity relationship

主题词 AMP活化蛋白激酶类(AMP-Activated Protein Kinases);钙-钙调素依赖性蛋白激酶激酶(Calcium-Calmodulin-Dependent Protein Kinase Kinase);钙(Calcium);磷酰化(Phosphorylation);查耳酮类(Chalcones)

DOI 10.1016/j.bioorg.2023.107048

PMID 38141328

发布时间 2024-01-24

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