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Effectiveness of L-serine supplementation in children with a <i>GRIN2B</i> loss-of-function mutation: Rationale and protocol for single patient (n-of-1) multiple cross-over trials.

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第一作者: Bibiche,den Hollander
第一单位: Amsterdam UMC Location University of Amsterdam, Department of Pediatrics, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, Amsterdam, the Netherlands.;Emma Personalized Medicine Center, Amsterdam UMC, Amsterdam, the Netherlands.;United for Metabolic Diseases, Amsterdam, the Netherlands.
作者单位: Amsterdam UMC Location University of Amsterdam, Department of Pediatrics, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, Amsterdam, the Netherlands.;Emma Personalized Medicine Center, Amsterdam UMC, Amsterdam, the Netherlands.;United for Metabolic Diseases, Amsterdam, the Netherlands. [1] HAN University of Applied Sciences, Nijmegen, the Netherlands. [2] Amsterdam UMC Location Vrije Universiteit Amsterdam, Child and Adolescent Psychiatry and Psychosocial Care, Emma Children's Hospital, Boelelaan 1117, Amsterdam, the Netherlands.;Amsterdam UMC Location University of Amsterdam, N=You Neurodevelopmental Precision Center, Amsterdam Neuroscience, Amsterdam Reproduction and Development, Meibergdreef 9, Amsterdam, the Netherlands. [3] United for Metabolic Diseases, Amsterdam, the Netherlands.;Amsterdam UMC Location University of Amsterdam, Department of Clinical Chemistry and Pediatrics, Laboratory Genetic Metabolic Diseases, Emma Children's Hospital, Meibergdreef 9, Amsterdam, the Netherlands.;Amsterdam Gastroenterology Endocrinology Metabolism, Inborn Errors of Metabolism, Amsterdam, the Netherlands.;Amsterdam UMC Location University of Amsterdam, Department of Core Facility Metabolomics, Meibergdreef 9, Amsterdam, the Netherlands. [4] Amsterdam UMC Location University of Amsterdam, Department of Hospital Pharmacy, Meibergdreef 9, Amsterdam, the Netherlands.;Medicine for Society, Platform at Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands. [5] Emma Personalized Medicine Center, Amsterdam UMC, Amsterdam, the Netherlands.;Advisium, 's Heerlen Loo Zorggroep, Amersfoort, the Netherlands.;Amsterdam UMC location University of Amsterdam, Department of Pediatrics, Emma Children's Hospital, Amsterdam Public Health Research Institute, Methodology and Mental Health and Personalized Medicine, Meibergdreef 9, Amsterdam, the Netherlands.;Amsterdam UMC location University of Amsterdam, Department of Pediatrics, Emma Children's Hospital, Amsterdam Reproduction & Development, Child Development, Meibergdreef 9, Amsterdam, the Netherlands. [6] University Medical Center Utrecht, Department of Data Science and Biostatistics, Julius Center for Health Sciences and Primary Care, Heidelberglaan 100, Utrecht, the Netherlands. [7] Emma Personalized Medicine Center, Amsterdam UMC, Amsterdam, the Netherlands.;Amsterdam UMC Location Vrije Universiteit van Amsterdam, Department of Human Genetics, Amsterdam Reproduction and Development, Meibergdreef 9, Amsterdam, the Netherlands. [8] Medicine for Society, Platform at Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.;Antoni van Leeuwenhoek, Department of Pharmacy and Clinical Pharmacology, Plesmanlaan 121, Amsterdam, the Netherlands. [9] Emma Personalized Medicine Center, Amsterdam UMC, Amsterdam, the Netherlands.;Amsterdam UMC Location Vrije Universiteit Amsterdam, Child and Adolescent Psychiatry and Psychosocial Care, Emma Children's Hospital, Boelelaan 1117, Amsterdam, the Netherlands.;Amsterdam UMC Location University of Amsterdam, N=You Neurodevelopmental Precision Center, Amsterdam Neuroscience, Amsterdam Reproduction and Development, Meibergdreef 9, Amsterdam, the Netherlands. [10] Amsterdam UMC Location University of Amsterdam, Department of Pediatrics, Emma Children's Hospital, Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, Amsterdam, the Netherlands.;Emma Personalized Medicine Center, Amsterdam UMC, Amsterdam, the Netherlands.;United for Metabolic Diseases, Amsterdam, the Netherlands.;Amsterdam UMC Location Vrije Universiteit van Amsterdam, Department of Human Genetics, Amsterdam Reproduction and Development, Meibergdreef 9, Amsterdam, the Netherlands. [11]
DOI 10.1016/j.conctc.2023.101233
PMID 38144875
发布时间 2024-03-27
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Contemporary clinical trials communications

Contemporary clinical trials communications

2023年36卷

101233页

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